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Some Psychological Factors Edegra, a drug used to treat Erectile Dysfunction, works by emphasizing the effectiveness of an already occurring physiological process at work during the development of an erection. Normally, this cyclical guanosine monophosphate is degraded by PDE5, a substance found in various tissues. PDE5 is reduced after taking Edegra, and this reduced quantity of the substance causes a corresponding increase in levels of cyclical guanosine monophosphate, and as a result, a strong erection takes place. Erectile Dysfunction Facts Impotence usually has a physical cause, such as disease, injury, or drug side-effects. Any disorder that impairs blood flow in the penis has the potential to cause impotence. It rises with age. About 5 percent of men at the age of 40 and between 15 and 25 percent of men at the age of 65 experience impotence.