Medication Research Methods

Medication disclosure and research is a costly procedure owing to the high expenses of Research and Development and human clinical tests. The cost of these researches is often from US$ 897 million to US$ 1.9 billion. The typical research time is 10-15 years. R&D of a new medication needs the identification of a target (e.g. protein) and the disclosure of some proper drug candidates that can deactivate or activate the target. The following phase of the process is clinical testing that takes a large amount of time and needs government permissions for its conducting. Food and Drug Administration (FDA) gives approvals to the medications that would be made in the US. As a result, modern drug discovery process is high-priced and arduous process that takes great pains.

One of the best ways to find challenging medication candidates is to investigate how the target protein interreacts with randomly selected compounds, which are normally an element of compound libraries. Usually chemists utilize high-throughput screening (HTS) for this kind of testing. There are also commercially available compound lists that include different compounds up to a few millions of samples. Compounds that become the most active ones are called hits. Such compounds greatly interact with the target. Some of these hits are then encouraged to lead compounds - candidate structures which are refined after that and changed in order to achieve better results and less side-effects.

Nowadays there are a few ways of drug design & discovery. The following are means for discovering a medication candidates, along with their advantages and disadvantages:

1. Virtual screening (VS) is a method that makes discoveries virtually as if there real screening were applied;

The main advantages of this method compared to laboratory experiments are:

- not so expensive, scientists won’t synthesize any compounds by themselves and so the expenses is not required for chemical process;

- it is possible to research compounds that have not been created yet;

- HTS is really costly and virtual screening gives a possibility to choose a number of helpful compounds for following HTS tests;

- huge amount of chemicals to look from.

There are available a great number of different elements in VS experiments in comparison with the quantity that gives high-throughput screening method. But the main disadvantage is that the process is not real and it can not perform all that may be seen during the real screening.

2. High-throughput screening is a real screening and it may use a large amount of elements a day. So researchers get genuine result during this way of drug discovery. But it needs huge funds.

These methods perform the reaction of a given target (protein) with different compounds. They may be used to help build theories about desirable chemical properties when designing the drug and, besides, they may be used to refine and transform medication candidates. Molecular Docking, Quantitative Structure-Activity Relationships (QSAR) and Pharmacopoeia Mapping are the means that are used nowadays in today drug discovery process. To get some more information about drug discovery service contact our internet page.

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